Optimizing Antibiotic Pharmacodynamics for Clinical Practice
نویسندگان
چکیده
In recent decades, emerging bacterial resistance is defying the efficacy of currently available antibiotics. Of the approximate 1.7 million hospital acquired infections in the US annually, a staggering 350,000 infections can be attributed to just a few multi-drug resistant pathogens [1-3]. Current consensus indicates Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter species, affectionately dubbed the “ESKAPE” pathogens, to be overwhelmingly responsible for the majority of antibiotic resistant infections found in US hospitals [4,5]. In the US alone, methicillin resistant S. aureus (MRSA) infections have been linked to higher mortality rates than HIV/AIDS and tuberculosis combined [6,7]. In addition to increased morbidity and mortality, figures from the Centers for Disease Control and Prevention (CDC) associate drug-resistant infections with an economic burden of approximately US$3.5 billion per year [2,3].
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